Beilstein J. Org. Chem.2021,17, 2832–2839, doi:10.3762/bjoc.17.194
cucurbit[n]urils can be used as non-toxic and safe drug carriers [29][30][31], among which cucurbit[8]uril (Q[8]) [32] has a large cavity. Q[8] interacts with a variety of small drug molecules such as chrysin, oroxinA and B, baicalein, etc., which can enhance the solubility, stability, antioxidant and
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Graphical Abstract
Figure 1:
The structures of chloramphenicol (A) and cucurbit[n]urils (B).
Beilstein J. Org. Chem.2020,16, 2332–2337, doi:10.3762/bjoc.16.194
–guest interactions between oroxinA (OA) and cucurbit[8]uril (Q[8]) using 1H NMR, MS, UV–vis and IR spectroscopy. The results showed that OA and Q[8] formed an inclusion compound (OA@Q[8]) with a molar ratio of 1:1 and a binding constant of 1.299 × 107 L·mol−1. In addition, the effect of Q[8] on the
the inclusion compound with Q[8].
Keywords: cucurbit[8]uril; host–guest interaction; inclusion complex; oroxinA; properties; Introduction
Cucurbit[n]urils (Q[n]s) are a family of macrocyclic cage compounds synthesized by the condensation of glycoluril and formaldehyde in a strong acidic solution [1
[21], can help to reduce the side effects and toxicity of the drug [22].
OroxinA (OA, baicalein-7-O-glucoside, Figure 1A) is one of the active ingredients isolated from the traditional herbal medicine Oroxylum indicum (L.) Kurz of Asian countries [23][24]. Accumulating studies have shown the
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Graphical Abstract
Figure 1:
The molecular structure of OA (A) and Q[8] (B).